Pregnancy and autoimmune connective tissue diseases

Connective tissue diseases and pregnancy.

Connective tissue diseases (CTD) such as systemic lupus erythematosus diffuse or limited systemic sclerosis and numerous others affect women frequently during the childbearing period. Every pregnancy in a patient with CTD should be regarded as high-risk pregnancy, and requires intensive monitoring and immediate treatment of clinical problems. For these reasons, for women suffering from CTD, who...

Renal involvement in autoimmune connective tissue diseases

Connective tissue diseases (CTDs) are a heterogeneous group of disorders that share certain clinical presentations and a disturbed immunoregulation, leading to autoantibody production. Subclinical or overt renal manifestations are frequently observed and complicate the clinical course of CTDs. Alterations of kidney function in Sjögren syndrome, systemic scleroderma (SSc), auto-immune myopathies...

Autoimmune and connective tissue disorders

Pregnant women with autoimmune rheumatic diseases, especially systemic lupus erythematosus (SLE) and systemic sclerosis, are at high risk of maternal disease flares, adverse fetal outcomes and potential drug teratogenic effects, making the management of these women particularly challenging. With improvements in diagnosis and treatment, however, these risks can be minimized by appropriate timing...

Neutrophilic Skin Lesions in Autoimmune Connective Tissue Diseases

The pathophysiology of neutrophilic dermatoses (NDs) and autoimmune connective tissue diseases (AICTDs) is incompletely understood. The association between NDs and AICTDs is rare; recently, however, a distinctive subset of cutaneous lupus erythematosus (LE, the prototypical AICTD) with neutrophilic histological features has been proposed to be included in the spectrum of lupus. The aim of our s...

Connective tissue diseases.